93 results found displaying 67-69
    
Rishi
 India
In Aid of AIDS Printer Friendly Version
A condition called Graft Versus Host Disease (GVHD) was foud among some immune deficient persons, who received bone marrow transplants. Later this condition came to light among certain patients, who were immune incompetent and who were transfused with blood products, which had immune competent cells. GVHD is not very common. But when it does happen it is often fatal. There seems to be no cure for this. Only prevention. Prevention is by using irradiated blood products.
Haemo-dialysis is a common procedure for alleviating kidney malfunction. The affected person's blood is pumped out, filtered, and put back into the patient online.
The virus causing HIV is not very hardy and is easily deactivated once it is outside the person.
The idea being proposed now combines the above three factors. Put an AIDS person on a dialysis type of machine, deactivate HIV by irradiating his/her blood to the currently practised doses of Gamma Irradiation, and put it back into the patient. Monitor the progression of AIDS and repeat the procedure.
At the least this may arrrest the progression of AIDS, and significantly improve the quality of life. At best it may effect a complete cure.
An adult has about a gallon and half of blood. With the blood irradiators currently available it should be possible to irradiate this quanity of blood to the prescribed dose of Gamma Rays in about half an hour. Since blood circulates through every nook and corner of the body, HIV lurking anywhere should get flushed into blood. The procedure is painless and can be repeated as often as haemo-dialysis, which is often done thrice a week.
The irradiator is rather expensive. But the running costs are negligible. The procedure does not conflict with any ongoing Anti Retroviral Treatment. Many can be treated in a day.
There is nothing out of the way in the proposal. All the procedures and equipment are known, available, and in routine use. The only new thing is the suggested application.
Unfortunately there does not seem to be a suitable animal model for trials. The trials probably have to be done on humans only. There is one soft option. Initially blood can be drawn from an AIDS patient and irradiated offline. Deactivation of HIV can be checked. If enough data points to this primary objective being met, the irradiated blood could be transfused to the same patient and monitored for any adverse reaction. If this also passes then a full scale online trial as suggested above can be done.
Reward: It is a crime to expect to be rewarded in this kind of case. 

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23°

    
Rishi
 India
3-D sound picture for the blind Printer Friendly Version
Polaroid Land use an ultrasonic auto focussing system. They also sell this alone as an experimental kit.
If two of these can be used on the whitcane used by the blind or on a helmet that the blind can wear, it should be possible to produce a stereo sound 'Image' of the surrounding. A far away object can produce a lower volume signal while a nearer one produces a higher volume sound. A larger object can produce a lower (Bass) note while a smaller object can produce a higher pitched sound. Even moving objects can be detected by adding a Doppler shift. An object going away will produce a descending scale, while an oncoming object can produce an ascending scale.
Microprocessors are quite cheap. Single chip audio amps are in plenty. All components are freely available.
It should help a lot of blind people to get a better "view" of their surroundings.
Since some of the objects themselves produce sounds, and this intereres, it is a simple matter to wear a pair of ear phones that get their input only from the sonar echo sounder.
Reward: Ideas are dime a dozen. Getting them to work is back breaking. The gadget will be helpful to people. Let the maker get her/his reward. 

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60°

    
Steve
 Austria
Smoker Therapy Printer Friendly Version
I've always heard that it's difficult to quit smoking even if you want to. Here's my suggestion: spend a voluntary night in hospital between two heavy smokers who look like skin and bones and are receiving treatment for severe cancer. Have their ex-wives walk in and let them chat for hours about their smoking habits, the surgery they already had, the size and looks of ulcers and the joys of chemotherapy. Have the smokers moan and groan from pain all night long.
I swear this would be much more effective than the warnings they put on cigarettes nowadays. And hospitals could earn some extra money buy offering this as a special to smokers who want to quit.
This has actually happened to me when I got my tonsils out. Unfortunately I didn't smoke in the first place.

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16°

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